Similarly Strong Purifying Selection Acts on Human Disease Genes of All Evolutionary Ages
نویسندگان
چکیده
منابع مشابه
Similarly Strong Purifying Selection Acts on Human Disease Genes of All Evolutionary Ages
A number of studies have showed that recently created genes differ from the genes created in deep evolutionary past in many aspects. Here, we determined the age of emergence and propensity for gene loss (PGL) of all human protein-coding genes and compared disease genes with non-disease genes in terms of their evolutionary rate, strength of purifying selection, mRNA expression, and genetic redun...
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To achieve dosage balance of X-linked genes between mammalian males and females, one female X chromosome becomes inactivated. However, approximately 15% of genes on this inactivated chromosome escape X chromosome inactivation (XCI). Here, using a chromosome-wide analysis of primate X-linked orthologs, we test a hypothesis that such genes evolve under a unique selective pressure. We find that es...
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At least 5% of the human genome predating the mammalian radiation is thought to have evolved under purifying selection, yet protein-coding and related untranslated exons occupy at most 2% of the genome. Thus, the majority of conserved and, by extension, functional sequence in the human genome seems to be nonexonic. Recent work has highlighted a handful of cases where mobile element insertions h...
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S1 pan-boreoeutherian mobile elements Mobile elements, as annotated by Repbase [1] and RepeatMasker [2], have a hierarchical naming convention where they are first broken down into classes, then families, and finally subfamilies. In the main text we define “pan-boreoeutherian” subfamilies to be the subfamilies that are present in primates (human, chimp, or rhesus), rodents (rat or mouse), and c...
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We tested whether functionally important sites in bacterial, yeast, and animal promoters are more conserved than their neighbors. We found that substitutions are predominantly seen in less important sites and that those that occurred tended to have less impact on gene expression than possible alternatives. These results suggest that purifying selection operates on promoter sequences.
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ژورنال
عنوان ژورنال: Genome Biology and Evolution
سال: 2009
ISSN: 1759-6653
DOI: 10.1093/gbe/evp013